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Lapho i-dihydrotanshinone ngibulala i-Helicobacter pylori, ayikwazi ukubhubhisa kuphela i-biofilm, kodwa futhi ibulale amabhaktheriya anamathiselwe ku-biofilm, edlala indima "ekususeni" iHelicobacter pylori.

UBi Hongkai, uSolwazi, iSikole Semithi Eyisisekelo, iNanjing Medical University

Imininingwane yakamuva yomdlavuza womhlaba ikhombisa ukuthi phakathi kwezigameko ezintsha zomdlavuza ezintsha ezibalelwa ku-4.57 ngonyaka eChina, zingu-480,000 izigameko ezintsha zomdlavuza esiswini, ezibalwa ngo-10.8%, ziphakathi kwamathathu aphezulu. E-China lapho kuba khona umdlavuza omkhulu esiswini, izinga lokutheleleka kwe-Helicobacter pylori lifinyelela kuma-50%, futhi inkinga yokumelana nama-antibiotic iya ngokuya iba yimbi kakhulu, okuholela ekwehleni okuqhubekayo kwezinga lokuqedwa.
Muva nje, ithimba likaProfesa Bi Hongkai, iSikole Sezokwelapha Eziyisisekelo, iNanjing Medical University, lihlole ngempumelelo umuntu ozobhalisela izidakamizwa weHelicobacter pylori-Dihydrotanshinone engazweli emithini. - I-Helicobacter pylori biofilm, ukuphepha nokumelana nokumelana, njll., Futhi kulindeleke ukuthi ingene ocwaningweni lwangaphambi kokuthola usizo njengomuntu olwa nezidakamizwa ze-Helicobacter pylori. Imiphumela yashicilelwa ku-inthanethi ephephabhukwini eligunyaziwe lamazwe omhlaba elwa namagciwane elithi "Antimicrobial Agents and Chemotherapy".

Izinga lokuqala lokwehluleka kokwelashwa kwemithi yendabuko cishe liyi-10%

Ngaphansi kwesibonakhulu, ubude bungama-micrometer ayi-2.5 kuya kuma-micrometer ayi-4 kuphela, kanti ububanzi ngama-micrometer ayi-0.5 kuya kuma-micrometer ayi-1 kuphela. I-Helicobacter pylori, ibhaktheriya eligobile ngokomoya "elisakaza amazipho nemidanso ngozipho", alikwazi nje ukubangela i-gastritis ebukhali futhi engalapheki, izilonda zesisu kanye ne-duodenal kanye ne-lymphatics. Izifo ezinjenge-gastric lymphoma ekhulayo nazo zihlobene nomdlavuza wesisu, umdlavuza wesibindi nesifo sikashukela.

Ukwelashwa okuphindwe kathathu nokuphindwe kabili okuqukethe ama-antibiotic amabili kuvame ukusetshenziswa ezweni lami ukwelapha iHelicobacter pylori, kepha izindlela zokwelashwa zendabuko azikwazi ukuqeda iHelicobacter pylori.

“Izinga lokwehluleka kokwelashwa kokuqala kokwelashwa kwesintu lilinganiselwa ku-10%. Ezinye iziguli zizoba nohudo noma ukuphazamiseka kwemifino emathunjini. Eminye iguliswa i-penicillin, futhi kunama-antibiotic ambalwa ongakhetha kuwo. Ngasikhathi sinye, ukusetshenziswa kwesikhathi eside kwama-antibiotic kuzobangela amabhaktheriya Ukuthuthukiswa kokumelana nemithi kwenza ukuthi ukusebenza kwama-antibiotic kube kubi kakhulu, futhi nomphumela wokuqedwa ngeke ufinyelelwe. ” UBi Hongkai uthe: “Amagciwane ayazwela kuma-antibiotics athile, futhi azophikisana namanye ama-antibiotic, futhi ukumelana nakho kungahluka ngezindlela ezahlukene. Amagciwane asakazekela komunye nomunye ngokusebenzisa izakhi zofuzo ezingazweli emishanguzweni, okwenza kube nzima ukumelana nemithi kwamagciwane. ”

Lapho iHelicobacter pylori imelana nokuhlasela kwesitha, ngobuqili iyozakhela yona “ikhava evikelayo” ye-biofilm, futhi i-biofilm izoba nokumelana nama-antibiotic, okuholele ekwandeni okukhulu kweHelicobacter pylori, ethinte umphumela wokwelapha futhi yehlise isilinganiso sokwelashwa.

Ukuhlolwa kweseli kweSalvia miltiorrhiza kungavimbela amagciwane amelana nemithi eminingi

Ngo-1994, i-World Health Organisation yahlukanisa i-Helicobacter pylori njenge-Carcinogen yeClass I ngoba idlala indima enkulu ekwenzekeni nasekuthuthukiseni umdlavuza wesisu. Ungasusa kanjani lo mbulali wezempilo? Ku-2017, iqembu likaBi Hongkai lenze ngempumelelo ngokuhlola kokuqala-iDanshen.

IDanshen ngomunye wemithi yendabuko esetshenziswa kakhulu yamaShayina yokukhuthaza ukujikeleza kwegazi nokususa i-stasis yegazi. Ukukhishwa kwawo okuncibilikayo okunamafutha kuyizakhi ze-tanshinone, kufaka phakathi ama-monomers angaphezu kwama-30 afana ne-tanshinone I, dihydrotanshinone, tanshinone IIA, ne-cryptotanshinone. Amakhemikhali e-Tanshinone anemiphumela ehlukahlukene yokwenziwa kwemithi, njenge-anti-cancer, ama-anti-positive bacteria, anti-inflammatory, estrogen-like activity kanye nokuvikelwa kwenhliziyo, njll, kepha umphumela we-anti-Helicobacter pylori awukabikwa.

“Phambilini, sihlolisise ama-monomers emithi yamaShayina angaphezu kuka-1 000 ezingeni leseli, futhi ekugcineni sathola ukuthi i-dihydrotanshinone I monomer eDanshen yaba nomthelela omuhle ekubulaleni iHelicobacter pylori. Lapho senza izivivinyo zamaseli, sithole ukuthi lapho ukusetshenziswa kwe-dihydrotanshinone bengikusebenzisa Uma kungu-0.125 μg / ml-0.5 μg / ml, kungavimbela ukukhula kwezinhlobo eziningi ze-Helicobacter pylori, kufaka phakathi ama-antibiotic-sensitive and multi-drug strains . ” U-Bi Hongkai uthe i-dihydrotanshinone I nayo iyasebenza kakhulu ekulweni ne-Helicobacter pylori kuma-biofilms. Umphumela omuhle wokubulala, kanti uHelicobacter pylori akazange akhulise ukumelana ne-dihydrotanshinone I ngesikhathi sokuqhubeka okuqhubekayo.

Isimanga esikhulu ukuthi “Uma i-dihydrotanshinone ngibulala iHelicobacter pylori, ayikwazi nje ukubhubhisa i-biofilm, kodwa futhi ibulale nama-bacteria axhumene ne-biofilm, edlala indima ekuqothulweni kwe-Helicobacter pylori. “UBi Hongkai wethule.

Ngabe i-Dihydrotanshinone ngiyiphulukisa i-Helicobacter pylori?

Ukuze kwenziwe imiphumela yokuhlola inembe kakhudlwana, ithimba likaBi Hongkai liphinde laqhuba izivivinyo zokuhlola amagundane ukuze kuqhutshekwe kutholakale umphumela wokubulala we-dihydrotanshinone I ku-Helicobacter pylori.

U-Bi Hongkai wethule ukuthi ekuhlolweni, emasontweni amabili ngemuva kokungenwa ngamagundane nge-Helicobacter pylori, abacwaningi babahlukanisa ngezikhathi ezithile baba ngamaqembu ama-3, okuyiqembu elihlangene lokuphatha i-omeprazole ne-dihydrotanshinone I, iqembu elijwayelekile lokuphathwa kwemithi emithathu, ne-phosphoric acid In iqembu lokulawula i-buffer, amagundane anikezwa umuthi kanye ngosuku ngezinsuku ezi-3 ezilandelanayo.

"Imiphumela yokuhlola ikhombisa ukuthi iqembu elihlangene lokuphatha i-omeprazole ne-dihydrotanshinone I linekhono eliphakeme ekubulaleni iHelicobacter pylori kuneqembu elijwayelekile lemithi ephindwe kathathu." U-Bi Hongkai uthe, okusho ukuthi kumagundane, i-dihydrotanshinone nginekhono lokubulala eliphakeme kunemithi yendabuko.

Ngabe i-Dihydrotanshinone ngizongena nini emakhaya abantu abajwayelekile? U-Bi Hongkai ugcizelele ukuthi iDanshen ayinakusetshenziswa ngqo ukuvikela nokwelapha ukutheleleka kwe-Helicobacter pylori, kanti ne-monomer yayo i-dihydrotanshinone I isekude ukwenziwa umuthi ongasetshenziswa emtholampilo. Uthe isinyathelo esilandelayo sizoqhubeka nokutadisha indlela yokusebenza kwe-dihydrotanshinone I, nokwenza ngcono i-pharmacology kanye ne-toxicology ye-dihydrotanshinone I ngokumelene ne-Helicobacter pylori. “Umgwaqo ongaphambili usekude. Ngiyethemba ukuthi izinkampani zingabamba iqhaza ocwaningweni lwangaphambi kokuthola usizo lwezempilo futhi ziqhubeke nalolu cwaningo ukuze kusizakale iziguli eziningi ezinezifo zesisu. ”